Changjiang Dong (董长江）

职称：教授，博导

通讯地址：9778818威尼斯文理学部测试中心

教育经历：

1999.03 至 2003.06 英国圣安德鲁斯大学化学生物学博士  

1988.09 至1991.06 四川大学生物化学硕士

工作经历：

2022.01 – 至今         9778818威尼斯二级教授

2012.02 – 2021.12   英国东英吉利亚大学分子医学教授

2008.09 – 2012.02   英国圣安德鲁斯大学惠康信托基金支持博后 

2007.01 - 2008.09    英国圣安德鲁斯大学 Eastchem博后 

2004.04 - 2007.01    英国圣安德鲁斯大学资深博士后

2002.03 - 2004.04    英国圣安德鲁斯大学博士后 

1998.09 - 2002.03    美国波士顿大学科研助理

2003.06 - 1998.09    四川大学讲师   

1991.07 - 2003.06    四川大学讲师助理

学术获奖：

Times杂志年度高校项目奖 (2015) 

惠康信托资深奖 (2015)

惠康信托发展奖 (2008) 

海外学生奖学金 (1999-2002) 

圣安德鲁斯大学奖学金 (1999-2002)  

研究成果：

长期从事感染与免疫的医学研究工作，利用交叉学科的研究手段，研究病原体与人体的相互作用，取得一系列具有国际影响力的成果。在《Nature》和《Science》上发表了8篇代表性研究论文。在对微生物感染研究中，明确了多个关键的抗原靶点结构与分子机制，提出了多种抗感染策略。

对于病毒的研究揭示了Lassa fever 病毒利用特殊的核酸酶逃脱人体免疫系统的全新机理。2022年猴痘疫情全球爆发后，随即开展了对猴痘病毒的持续深入研究，阐明了猴痘遗传物质DNA解旋、复制及扩增的复杂分子机制；解析了关键蛋白分子机器复合体高分辨率冷冻电镜结构；揭示了FDA批准化合物Brincidofovir和Cidofovir抑制猴痘病毒DNA复制全酶复合体的分子机制。这一系列关于猴痘病毒的研究对于猴痘病毒感染传播分子机制的理解，抗猴痘病毒的药物防治策略以及未来的抗猴痘药物设计指导均具有深远的意义。

对于细菌的感染问题，在过去的10年时间系统的研究了革兰氏阴性细菌外膜关键靶点成分脂多糖以及外膜蛋白相关的多个分子机器复合体的工作分子机制，对于针对脂多糖转运系统以及外膜蛋白折叠系统的药物设计提供了新的研究视角。

承担主要科研项目：

惠康信托资深项目:    £1,703,167 (2015)

医学研究会项目:      £617,500 (2012)  

惠康信托发展项目:       £759,877 (2008)

英国皇家学会项目:    £12,000 (2012)

英国皇家学会国际项目 2008/R3NSFC:    £12,000 (2008)

惠康信托领军项目（参与）:    £5,000,000 (2008)

生物技术&生物科学研究会（ 合作主持）  £2,060,000 (2004)

学术兼职:

瑞士国家科学基金委国家研究中心AntiResist 项目国际专家组成员

 Frontiers in Microbiology 副主编 

代表性论著：

1. Tang X, Chang S, Zhang K, Luo Q, Zhang Z, Wang T, Qiao W, Wang C, Shen C, Zhang Z, Zhu X, Wei X, Dong C, Zhang X, Dong H. Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat Struct Mol Biol. 2021 Apr;28(4):347-355. doi: 10.1038/s41594-021-00573-x. Epub 2021 Mar 29.PMID: 33782615 （共通讯）

2. Tang X, Chang S, Qiao W, Luo Q, Chen Y, Jia Z, Coleman J, Zhang K, Wang T, Zhang Z, Zhang C, Zhu X, Wei X, Dong C, Zhang X, Dong H. Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat Struct Mol Biol. 2020 Nov 16. doi: 10.1038/s41594-020-00532-y. PMID: 33199922. （共通讯）

3. Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, Coleman J, Dong C, Li N, Huang J, Xu C, Zhang Z, Gao S, Zhou P, Ding K, Chen L. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020 Jun 8;12(6):e11571. doi: 10.15252/emmm.201911571. PMID: 32391629

4. Tang X, Chang S, Luo Q, Zhang Z, Qiao W, Xu C, Zhang C, Niu Y, Yang W, Wang T, Zhang Z, Zhu X, Wei X, Dong C, Zhang X, Dong H. Cryo-EM structures of lipopolysaccharide transporter LptB ₂ FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism. Nat Commun. 2019 Sep 13;10(1):4175. doi: 10.1038/s41467-019-11977-1. （共通讯）

5. Sequeira S, Kavanaugh D, MacKenzie DA, Šuligoj T, Walpole S, Leclaire C, Gunning AP, Latousakis D, Willats WGT, Angulo J, Dong C, Juge N. Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe-host interactions. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2706-E2715. doi: 10.1073/pnas.1715016115. Epub 2018 Mar 5. （共通讯）

6. Dong H, Zhang Z, Tang X, Paterson NG, Dong C. Structural and functional insights into the lipopolysaccharide ABC transporter LptB₂FG. Nat Commun. 2017 Aug 9;8(1):222. doi: 10.1038/s41467-017-00273-5. （共通讯）

7. Gu Y, Li H, Dong H, Zeng Y, Zhang Z, Paterson NG, Stansfeld PJ, Wang Z, Zhang Y, Wang W, Dong C. Structural basis of outer membrane protein insertion by the BAM complex. Nature. 2016 Mar 3;531(7592):64-9. doi: 10.1038/nature17199. （共通讯）

8. Dong H, Xiang Q, Gu Y, Wang Z, Paterson NG, Stansfeld PJ, He C, Zhang Y, Wang W, Dong C. Structural basis for outer membrane lipopolysaccharide insertion. Nature. 2014 Jul 3;511(7507):52-6. doi: 10.1038/nature13464. （共通讯）

9. Qi X, Lan S, Wang W, Schelde LM, Dong H, Wallat GD, Ly H, Liang Y, Dong C. Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature. 2010 Dec 9;468(7325):779-83. （独立通讯）

10. Wang W, Black SS, Edwards MD, Miller S, Morrison EL, Bartlett W, Dong C, Naismith JH, Booth IR. The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution. Science. 2008 Aug 29;321(5893):1179-83.

11. Dong C, Beis K, Nesper J, Brunkan-Lamontagne AL,Clarke BR, Whitfield C, Naismith JH. Wza the translocon for E.coli capsular polysaccharides defines a new class of membrane protein. Nature: 2006, 444:226-9.（共同第一作者）

12. Dong C, Flecks S, Unversucht S, Haupt C, van Pee KH, Naismith JH.Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Science. 2005 Sep 30;309(5744):2216-9. （第一作者）

13. Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH.Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature. 2004 Feb 5;427(6974):561-5. （第一作者）

14. Shen L, Tatham MH, Dong C, Zagorska A, Naismith JH & Hay RT. SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nature struc & mol biology. 2006, 13(12):1069-77. Epub 2006 Nov 12.

15. Collins R, Beis K, Dong C, Botting C, McDonnel C, Ford R, Clarke B, Whitfield C & Naismith J. The 3-D structure of a novel periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli. Proc Natl Acad Sci U S A, 2007,104(7):2390-5.

16. Shen LN, Liu H, Dong C, Xirodimas D, Naismith JH, Hay RT. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6;24(7):1341-51.

17. Gu Y, Stansfeld PJ, Zeng Y, Dong H, Wang W, Dong C. Lipopolysaccharide is Inserted into the Outer Membrane through An Intramembrane Hole, A Lumen Gate, and the Lateral Opening of LptD. Structure. 2015 Mar 3;23(3):496-504. （独立通讯）

18. Li X, Gu Y, Dong H, Wang W, Dong C. Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane. Sci Rep. 2015 Jul 7;5:11883. doi: 10.1038/srep11883. （独立通讯）

19. Huang Q, Shao J, Lan S, Zhou Y, Xing J, Dong C, Liang Y, Ly H. In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions. J Virol. 2015 Jul;89(13):6595-607. doi: 10.1128/JVI.00009-15. Epub 2015 Apr 15.

20. Dong H, Li P, Elliott RM, Dong C.Structure of Schmallenberg orthobunyavirus nucleoprotein suggests a novel mechanism of genome encapsidation. J Virol. 2013 May;87(10):5593-601. （独立通讯）

21. Flecks S, Patallo EP, Zhu X, Ernyei AJ, Seifert G, Schneider A, Dong C, Naismith JH, van Pée KH. New insights into the mechanism of enzymatic chlorination of tryptophan. Angew Chem Int Ed Engl. 2008;47(49):9533-6.

22. Tran AX, Dong C, Whitfield C. Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli. J Biol Chem. 2010 Oct 22;285(43):33529-39

23. Wallat GD, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions. PLoS One. 2014 Feb 7;9(2):e87577. doi: 10.1371/journal.pone.0087577.

24. Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH. The structural basis of chain length control in Rv1086. J Mol Biol. 2008 Aug 1;381(1):129-40

25. Dong C, Major LL, Srikannathasan V, Errey JC, Philp D, Asuncion M,Giraud MF, Lam J,Graninger M Messner P, McNeil MR, Field RA, Whitfield C & Naismith JH. RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol 2007 Jan 5;365(1):146-59. Epub 2006 Sep 29.

26. Van Pee KH, Dong C, Flecks S, Naismith J, Patallo EP, Wage T. Biological halogenation has moved far beyond haloperoxidases. Adv Appl Microbiol 2006; 59:127-57

27. Shen L, Dong C, Liu H, Naismith JH, Hay RT. The structure of SENP1 SUMO-2 co-complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J. 2006 Jul;15; 392(2):279-88

28. Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH. High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme. Structure. 2003 Jun;11(6):715-23.