周小菊（Zhou Xiaoju）                                        

职务/职称: 副教授

办公地址：9778818威尼斯医学研究院8号楼808室

通讯地址（含邮编）：武汉市武昌区东湖路185号 9778818威尼斯 430071

学习简历：

1994.9 - 1998.6 同济医科大学9778818威尼斯药学专业，获理学学士学位

2001.9 - 2004.6 华中科技大学同济医学院9778818威尼斯，获药剂学理学硕士学位

2005.9 - 2008.12 9778818威尼斯化学与分子科学学院，获有机化学博士学位

工作简历：

1998.7 - 2001.8 武汉瑞德生物制品有限公司从事质检工作,执业药师

2004.7 - 至今   9778818威尼斯从事药剂学专业的教学科研工作

2011.6 - 2012.6 美国俄亥俄州立大学9778818威尼斯Robert J. Lee实验室博士后

2017.8 - 2018.7 美国俄亥俄州立大学9778818威尼斯和Wexner医学中心访问学者

2018.7 - 2022.7 美国印第安纳州立大学医学院再生医学与工程中心Chandan K.  Sen实验室博士后

研究领域:

药剂学、再生医学、肿瘤治疗、创面修复等

研究兴趣与方向:

1. 外泌体、脂质体及高分子材料作为小分子药物和大分子核酸药物的靶向给药系统的研究；

2. 外泌体中活性成分对疾病发生发展影响的研究；

3. 噬菌体用于感染性疾病的治疗研究；

4. 肿瘤治疗及创面修复的研究。

承担课题与经费：

1) 主持国家自然科学基金面上基金项目（No.82273875, 2022 - 2026）

2) 主持国家自然科学基金青年基金项目（No.81402882, 2015 - 2017）

3) 主持中央高校专项科研基金项目（No.3082035）

4) 参与国家自然基金四项（No.20575050，2972121，81273363，81571811)

5) 参与武汉市应用基础研究计划项目一项

6）承担9778818威尼斯医学部教改项目2项

教学情况：

主讲本科生课程: 药剂学理论课及实验课，生物药剂学与药物动力学

主要科研成果:

1. 代表性论文

1) Xiaoju Zhou^#, Brooke A. Brown, Amanda P. Siegel, Mohamed S. El Masry, et al. Exosome-mediated crosstalk between keratinocytes and macrophages in cutaneous wound healing. ACS Nano, 2020, 14, 12732−12748.

2) Mingxing Qiu#, Jiong Wang#,Chaoran Zheng, Jiaojiao Bai, Zhi Liu, Andrew R. Clark, Xinwei Cheng, Xiaoyan Liao, Robert J. Lee, Xiaoju Zhou*. Dual-ligand Functionalized Liposomes for Hepatocellular Carcinoma Targeting and Therapy. s (in submission)

3) 邱明星，白娇娇，周小菊*，免疫脂质体作为靶向给药系统的研究进展，中国医药工业杂志，2020，51（3）：316-324.

4）Xiaoju Zhou^*,#, Pengyu Wang^#, Jiong Wang, Zhi Liu，Xuechuan Hong, Yuling Xiao, Peng Liu, Xianming Hu. Hydroxyethyl Pachyman as a novel excipient for sustained-release matrix tablets. Carbohydrate Polymers, 2016, 154:1-7.

5) Zhigang Rao^#, Hao Hu, Jiazhi Tang, Zhiying Liu, Yue Yang, Guofu Qiu, Yuling Xiao, Peng Liu, Xiaoju Zhou*, Xuechuan Hong*. Steroidal ammonium compounds as new neuromuscular blocking agents. Chemical Biology & Drug Design, 2016, 8: 73-783

6) Zhiming Wang^#, Jinpin Li, Xiaodong Zeng, Xianming Hu, Xiaoju Zhou*, Xuechuan Hong*. Synthesis and pharmacological evaluation of novel benzenesulfonamide derivatatives as potential anticonvulsant agents.Molecules, 2015, 20(9): 17585-17600.

7）Xiaoju Zhou^#， Jiong Wang, Jianhong Wu, Xiaojuan Yang, Bryant C. Yung, L. James Lee, Robert J. Lee*. Preparation and evaluation of a novel liposomal formulation of cisplatin. European Journal of Pharmaceutical Sciences, 2015, 66: 90-95.

8）Mengzi Zhang, Xiaoju Zhou, Bo Wang, Bryant C. Yung, Ly J. Lee, Kalpana Ghoshal, Robert J. Lee*. Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma. Journal of controlled release, 2013, 168: 252-261.

9）Xiaoju Zhou^#, Mengzi Zhang^#, Hong Li, Chenguang Zhou, Robert J. Lee*. Liver targeting and antitumor activity of doxorubicin liposomes modified with a novel galactosylated lipid. International Journal of Nanomedicine, 2012, 7: 5465–5474.

10）Xiaoju Zhou^#, Bryant Yung, Hong Li, Xianming Hu, Robert J. Lee*. A novel liposomal gefitinib formulation.Anticancer Research, 2012, 32(7): 2919-23.

11）Xiaoju Zhou^#, Yan Hu, Yanping Tian, Xianming Hu*. Effect of N-trimethyl chitosan enhancing the dissolution properties of lipophilic drug cyclosporin A. Carbohydrate Polymers, 2009, 76(2): 285-290.

12）Yan Hu^#, Xiaoju Zhou, Yong Lu, Chengyang Hu, Xianming Hu. Novel biodegradable hydrogels based on pachyman and its derivatives for drug delivery. International Journal of Pharmaceutics, 2009, 371: 89-98.

13）Xiaoju Zhou^#, Yimu Yi, Wan Jing, Xianming Hu*. Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles. Drug Development and Industrial Pharmacy, 2008，9(16): 1- 6.

2.会议论文：

1）Xiaoju Zhou^#, Deepak S. Chuanhan,Sayak Bhattacharya, Amitavaa, Das, Sashwati Roy, Subhadip Ghatak and Chandan K. Sen.siRNA functionalized targeted lipid nanoparticles to manipulate exosomal microRNA packaging in keratinocytes, Ohio Valley Society of plastic surgeons,63rd meeting, 2019, June 5-6, poster.

2) Xiaoju Zhou^#, Amanda Siegel, Brook Brown, Mohamed EI Marsry, et al. Keratinocyte-derived exosomal packaging drives conversion of injury-site macrophage in granulation tissue of murine wound. International Society for Extracellular Vesicles (ISEV) meeting, 2020, July 15, poster.

3) Xiaoju Zhou^#, Hui Ming, Xianming Hu. Novel liposomes modified with glycyrrhetinic acid as a liver-targeting delivery system，中国药物制剂大会论文集, PP258, 武汉, 2013.10.26-27, 论文及墙报

4) Hui Ming, Shuai Shi, Xiaoju Zhou*, Xianming Hu*. Synthesis and anti-tumor activity of lactobionic acid-modified glycyrrhetinic acid, 国际药学前沿科学研讨会暨湖北省药物化学与抗生素学术会议论文集, pp32, 武汉，2013.12.24.

5) 章敏, 明惠, 周小菊*, 胡先明*. 乳糖酸改性甘草次酸的合成及游离羧基对其抗肿瘤活性的影响研究.国际药学前沿科学研讨会暨湖北省药物化学与抗生素学术会议论文集, pp32, 武汉，2013.12.24.

3.专利

1) 周小菊，李剑光，赵孝斌.一种新型铂类脂质体制剂及其制备方法，申请号：201210281809.7

2) 周小菊，王炯，胡先明，等. 羟乙基茯苓多糖的制备及其作为缓释骨架片材料的应用. 专利号: ZL201610548947.5