陶韦新

性别：男

职务/职称：副教授

通讯地址：9778818威尼斯（文理学部分析测试中心C408）

学习经历与工作简历

2023至今：9778818威尼斯，副教授

2014-2023：9778818威尼斯，讲师

2011-2013：9778818威尼斯基础医学博士后流动站，博后

2008-2011：Dong-A University (Korea)，博士

2006-2008：广东中大南海海洋生物技术国家工程中心，研究人员

2003-2006：华中农业大学生命科学技术学院，硕士

业绩概要

研究内容聚焦于“基因组学指导下微生物天然产物的生物合成研究及资源挖掘”，包括（一）基于基因/基因组信息解析微生物天然产物的生物合成机制，利用合成生物学技术高产或创新微生物天然产物药物分子；（二）基于基因组信息挖掘微生物天然产物资源及相应技术方法的建立；相关研究成果发表于Angewandte Chemie International Edition、Chemical Science、Science China Chemistry、mBio、Applied and Environmental Microbiology、Frontiers in Microbiology、ACS Synthetic Biology、Journal of Biotechnology等期刊。

获奖情况

2016年 “A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis” 获第十六届湖北省自然科学优秀学术论文二等奖

2014年 “Unusual acetylation-elimination in the formation of tetronate antibiotics” 获第十五届湖北省自然科学优秀学术论文一等奖

研究领域及研究兴趣

1.基于基因组信息挖掘微生物天然产物及其生物合成基因簇资源；

2.微生物天然产物生物合成基因簇克隆、编辑、异源表达技术平台的搭建；

3.分子水平上解答微生物天然产物生物合成中的关键问题，并利用合成生物学技术编辑其生物合成路径实现活性药物分子的高产或创新。

承担课题与经费

1.国家重点研发计划子课题（2018YFA0903203，2019-2024），57万，主持；

2.国家自然科学基金青年基金（31300061；2014-2016），23万，主持；

3.中国博士后科学基金面上资助（2012M521461；2012-2014），5万，主持；

教学情况

本科生课程：生物化学实验，分子生物学

发表学术论文（#第一作者，*通讯作者）

1.Tao WX,* Chen L, Zhao CH, Wu J, Yan DZ, Deng ZX, Sun YH.* 2019. In vitro packaging mediated one-step targeted cloning of natural product pathway. ACS Synth Biol. 8(9):1991-1997.

2.Kong LY,# Xu GD,# Liu XQ, Wang JW, Tang ZL, Cai YS, Shen K, Tao WX, Zheng Y, Deng ZX, Price NPJ, Chen WQ.* 2019. Divergent biosynthesis of C-nucleoside minimycin and indigoidine in bacteria. iScience. 22:430-440.

3.Tao WX, Yang AN, Deng ZX, Sun YH.* 2018. CRISPR/Cas9-based editing of Streptomyces for discovery, characterization and production of natural products. Front Microbiol. 9:1660.

4.Lee MH,# Khan R,# Tao WX,# Choi KH, Lee SY, Lee JW, Hwang EC, Lee SW.* 2018. Soil metagenome-derived 3-hydroxypalmitic acid methyl ester hydrolases suppress extracellular polysaccharide production in Ralstonia solanacearum. J Biotechnol. 270:30-38.

5.Liu YZ, Chen X, Li ZY, Xu W, Tao WX, Wu J, Yang J, Deng ZX, Sun YH.* 2017. Functional analysis of cytochrome P450s involved in streptovaricin biosynthesis and generation of anti-MRSA analogues. ACS Chem Biol. 12(10):2589-2597.

6.Havemann J, Yurkovich ME, Jenkins R, Harringer S, Tao WX, Wen SS, Sun YH, Leadlay PF,* Tosin M.* 2017. Chemical probing of thiotetronate bio-assembly. Chem Commun (Camb). 53:1912-1915.

7.Tao WX,# Yurkovich ME,# Wen SS,# Lebe KE, Samborskyy M, Liu YZ, Yang AN, Liu YK, Ju YC, Deng ZX, Tosin M, Sun YH,* Leadlay PF.* 2016. A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chem Sci. 7:376-385.

8.Liu YK,# Tao WX,# Wen SS, Li ZY, Yang AN, Deng ZX, Sun YH.* 2015. In vitro CRISPR/Cas9 system for efficient targeted DNA editing. mBio. 6:e01714-15.

9.Wu J, Kong HG, Jung EJ, Choi SY, Lee HJ, Tao WX, Chung ES, Lee SW.* 2015. Loss of glutamate dehydrogenase in Ralstonia solanacearum alters dehydrogenase activity, extracellular polysaccharide production and bacterial virulence. Physiol Mol Plant P. 90:57-64.

10.Zhao CH,* Qi JZ, Tao WX, He L, Xu W, Chan J, Deng ZX.* 2014. Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5’-O-sulfonamide moiety in Streptomyces sp. JCM9888. PloS One. 9(12):e114722.

11.Tao WX,# Zhu MH,# Deng ZX, Sun YH.* 2013. Biosynthesis of tetronate antibiotics: a growing family of natural products with broad biological activities. Sci China Chem. 56:1364-1371.

12.Kanchanabanca C,# Tao WX,# Hong H, Liu YJ, Hahn F, Samborskyy M, Deng ZX, Sun YH,* Leadlay PF.* 2013. Unusual acetylation-elimination in the formation of tetronate antibiotics. Angew Chem Int Edit. 52:5785-5788.

13.Tao WX, Lee MH, Wu J, Kim NH, Kim JC, Chung ES, Hwang EC, Lee SW.* 2012. Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase. Appl Environ Microbiol. 78:6295-6301.

14.Tao WX, Lee MH, Yoon MY, Kim JC, Malhotra S, Wu J, Hwang EC, Lee SW.* 2011. Characterization of two metagenome-derived esterases that reactivate chloramphenicol by counteracting chloramphenicol acetyltransferase. J Microbiol Biotechnol. 21:1203-1210.

15.Tao WX, Lee MH, Wu J, Kim NH, Lee SW.* 2011. Isolation and characterization of a family VII esterase derived from alluvial soil metagenomic library. J Microbiol. 49:178-185.

16.Lee MH, Hong KS, Malhotra S, Park JH, Hwang EC, Choi HK, Kim YS, Tao WX, Lee SW.* 2010. A new esterase EstD2 isolated from plant rhizosphere soil metagenome. Appl Microbiol Biotechnol. 88:1125-1134.

17.Li WC,# Wu J,# Tao WX, Zhao CH, Wang YM, HE XY, Chandra G, Zhou XF, Deng ZX, Chater KF, Tao MF.* 2007. A genetic and bioinformatics analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiol Lett. 266:20-28.