Background/Biography

Education:

1997/09-2000/07：Ph.D. in Organic Chemistry, Sichuan University, China.

1994/09-1997/07：M.S. in Organic Chemistry, Sichuan University, China.

1990/09-1994/07：B.S. in Chemistry, Yan’an University, China.

Work experience:

2007/09-present: Professor, Wuhan University School of Pharmaceutical Sciences, China.

2003/12-2007/11: Postdoctoral associate, University of Illinois at Urbana-Champaign, USA.

2001/09-2003/12: Postdoctoral fellow, University of Ottawa, Canada.

2000/08-2001/08: Research assistant, The University of Kong Kong, China.

Honors & Awards：

1. Chair Professor of Luojia Scholarship of Wuhan University in 2012.

2. The WuXi PharmaTech Life Science and Chemistry Award in 2010.

3. Selected for New Century Excellent Talents in 2009.

Teaching:

Advanced Organic Chemistry, Medicinal Chemistry.

Research interests:

Anti-virus/anti-tumor drugs discovery

Publications:

1)Novel Bioactive Hybrid Compounds Dual Targeting Estrogen Receptor and Histone Deacetylase for Treatment of Breast Cancer. Chu Tang, Changhao Li, Silong Zhang, Zhiye Hu, Jun Wu, Chune Dong*, Jian Huang*, and Hai-Bing Zhou*. J. Med. Chem. 2015, 58 (11), 4550-4572. (IF: 5.447) (One of Most Read Top 20 Articles of the Month; Highlighted by BioCentury Innovations (Formerly SciBX, Science-Business eXchange) on June 25, 2015)

2)Tunable Bifunctional Phosphine Squaramide Promoted Morita-Baylis-Hillman Reaction of N-alkyl Isatins with Acrylates. Ze Dong, Chao Yan, Yongzhi Gao, Chune Dong, Guofu Qiu*, Hai-Bing Zhou*. Adv. Synth. Catal. 2015, 357 (9), 2132–2142. (IF: 5.663).

3)Synthesis of N-benzyl-N-phenylthiophene-2-carboxamide Analogues as a Novel Class of Enterovirus 71 Inhibitors. Jiawei Pan, Xin Han, Ningyuan Sun, Haoming Wu, Dandan Lin, Po Tien, Hai-Bing Zhou* and Shuwen Wu*. RSC Adv., 2015, 5 (31), 55100-55108. (IF: 3.840)

4)Recyclable BINOL-Quinine-Squaramide as Highly Efficient Organocatalyst for α-Amination of 1, 3-Dicarbonyl Compounds and α-Cyanoacetates. Yongzhi Gao, Bin Liu, Wei Wang, Hai-Bing Zhouand Chune Dong*. RSC Adv., 2015, 5 (31), 24392-24396. (IF: 3. 840)

5)Halolactones are Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. X. Han, H. Wu, C. Dong, P. Tien, W. Xie, S. W. Wu*, H.-B. Zhou*. RSC Adv., 2015, 5 (13), 10005-10013. (IF: 3. 840)

6)Estrogen receptor-targeted fluorescent probes and bioapplications. Lu Yang, Chu Tang, Hai-Bing Zhou*. SCIENTIA SINICA Chimica 2015, 45 (9), 937–948.

7)Synthesis and SARs of Indole-based α-Amino Acids as Potent HIV-1 Non-Nucleoside Reversed Transcriptase Inhibitors. Xin Han, Haoming Wu, Wei Wang, Chune Dong, Po Tien, Shuwen Wu*, Hai-Bing Zhou*. Org. Biomol. Chem., 2014, 12 (41), 8308 - 8317. (IF: 3.562)

8)Triaryl-substituted Schiff Bases are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor. Zong-Quan Liao, Chune Dong, Kathryn E. Carlson, Sathish Srinivasan, Jerome C. Nwachukwu, Robert W. Chesnut, Abhishek Sharma, Kendall W. Nettles, John A. Katzenellenbogen,* and Hai-Bing Zhou*. J. Med. Chem. 2014, 57 (8), 3532-3545.(IF: 5.447)

9)C3-Symmetric Cinchonine-Squaramide-Catalyzed Asymmetric Chlorolactonization of Styrene-Type Carboxylic Acids with 1,3-Dichloro-5,5-dimethylhydantoin: An Efficient Method to Chiral Isochroman-1-ones. Xin Han, Chune Dong, and Hai-Bing Zhou*. Adv. Synth. Catal.2014, 356 (6), 1275–1280. (IF: 5.663).

10)One-pot to fused pyrazoles by a double cyclization of o-alkynylaldehydes with ketones and hydrazine under metal-free condition, Jinxia Qiao, Bin Liu, Zongquan Liao, Ying Li, Lei Ma, Chune Dong, and Hai-Bing Zhou*. Tetrahedron 2014, 70 (24), 3782-3787. (IF: 2.641)

11)Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non-racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts. Xin Han, Wenjie Ouyang, Bin Liu, Wei Wang*, Po Tien, Shuwen Wu*, Hai-Bing Zhou*. Org. Biomol. Chem., 2013, 11 (48), 8463-8475. (IF: 3.487)

12)Design, Synthesis and Biological Evaluation of Novel Estrogen-derived Steroidal Metal Complexes. Xinlong Zhang, Ziqing Zuo, Juan Tang, Kai Wang, Caihua Wang, Weiyan Chen, Changhao Li, Wen Xu, Xiaolin Xiong, Kangxiang Yuntai, Jian Huang, Xiaoli Lan, Hai-Bing Zhou*. Bioorg. Med. Chem. Lett.2013, 23(13), 3793-3797. (IF: 2.331)

13)Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity. Jian Min, Pengcheng Wang, Sathish Srinivasan, Jerome C. Nwachukwu, Pu Guo, Minjian Huang, Kathryn E. Carlson, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. J. Med. Chem., 2013,56 (8), 3346–3366. (IF: 5.480)

14)Identification and Structure-Activity Relationships of a Novel Series of Estrogen Receptor Ligands Based on 7-Thiabicyclo[2.2.1]hept-2-ene-7-oxide. Pengcheng Wang, Jian Min, Jerome C. Nwachukwu, Valerie Cavett, Kathryn E. Carlson, Pu Guo, Manghong Zhu, Yangfan Zheng, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. J. Med. Chem. 2012, 55(5), 2324-2341. (IF: 5.614)

15)An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3-Symmetric Cinchonine-Squaramide Catalysts. Xin Han, Xiangfei Wu, Chang Min, Hai-Bing Zhou, Chune Dong*. RSC Advances 2012, 2 (19), 7501-7505.

16)Synthesis, biological evaluation and structure activity relationships of new estrogen receptor ligands based on a bridged oxabicyclic core embellished with arylsulfonamides. Manghong Zhu, Chen Zhang, Jerome C. Nwachukwu, Sathish Srinivasan, Valerie Cavett, Yangfan Zheng, Kathryn E. Carlson, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. Org. Biomol. Chem., 2012, 10(43), 8692-8700. (IF: 3.568)

17)Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells. Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Wenming Ren, Chune Dong, Jian Huang*, Hai-Bing Zhou*. Org. Biomol. Chem., 2012, 10(48), 9689-9699. (IF: 3.568)

18)Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2.2.1]hept-5-ene Scaffold Core Ligands. Yangfan Zheng, Manghong Zhu, Sathish Srinivasan, Jerome C. Nwachukwu, Valerie Cavett, Jian Min, Kathryn E. Carlson, Pengcheng Wang, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, Hai-Bing Zhou*. ChemMedChem2012, 7(6), 1094-1100. (IF: 2.835)

19)C3-Symmetric Cinchonine-Squaramide as New Highly Efficient, and Recyclable Organocatalyst for Enantioselective Michael Addition. Chang Min, Xin Han, Zongquan Liao, Xiangfei Wu, Hai-Bing Zhou, Chune Dong*. Adv. Synth. Catal. 2011, 353 (14-15), 2715–2720. (IF: 6.048).

20)Metal-free Direct Amidation of Peptidyl Thiol Esters with α-Amino Esters. Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng. Green. Chem. 2011, 13, 2723-2726. (IF: 6.320)

21)Imaging progesterone receptor in breast tumors: Synthesis and receptor binding affinity of fluoroalkyl-substituted analogs of Tanaproget.Hai-Bing Zhou, Jae Hak Lee, Christopher G. Mayne, Kathryn E. Carlson, John A. Katzenellenbogen*, J. Med. Chem. 2010, 53 (8), 3349–3360. (IF: 5.207)

22)Development of [F-18]Fluorine-Substituted Tanaproget as a Progesterone Receptor Imaging Agent for Positron Emission Tomography. Jae Hak Lee, Hai-Bing Zhou, Carmen S. Dence, Kathryn E. Carlson, Michael J. Welch, John A. Katzenellenbogen*, Bioconjugate Chem. 2010,21 (6), 1096-1104. (IF: 5.002)

23)Analogs of methyl-piperidinopyrazole (MPP): Antiestrogens with estrogen receptorselective activity. Hai-Bing Zhou, Kathryn E. Carlson, Fabio Stossi, Benita S. Katzenellenbogen, John A. Katzenellenbogen*. Bioorg. Med. Chem. Lett. 2009, 19 (1), 108-110. (IF: 2.650)

24)Bromination from the Macroscopic Level to the Tracer Radiochemical Level: 76Br Radiolabeling of Aromatic Compounds via Electrophilic Substitution. Dong Zhou, Haibing Zhou, Carl C. Jenks, Jason S. Lewis, John A. Katzenellenbogen, and Michael J. Welch*. Bioconjugate Chem. 2009, 20 (4) 808-816. (IF: 4.350)

25)NFkB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. K. W. Nettles*, J. B. Bruning, G. Gil, J. Nowak, S. K. Sharma, J. B. Hahm, K. Kulp, R. B. Hochberg, H. B. Zhou, J. A. Katzenellenbogen, B. S. Katzenellenbogen, Y. Kim, A. Joachmiak, G. G. Greene, Nature Chemical Biology 2008, 4 (4), 241-247. (IF: 14.612)

26)Elemental Isomerism: A Boron-Nitrogen Surrogate for a Carbon-Carbon Double Bond Increases the Chemical Diversity of Estrogen Receptor Ligands. Hai-Bing Zhou, Kendall W. Nettles, John B. Bruning, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, Fabio Stossi, Benita S. Katzenellenbogen, Geoffrey L. Greene and John A. Katzenellenbogen*, Chemistry & Biology 2007, 14 (6), 659-669. (IF: 5.718)

27)Bicyclo[2.2.2]octanes: Close Structural Mimics of the Nuclear Receptor-binding Motif of Steroid Receptor Coactivators. Hai-Bing Zhou, Margaret L. Collins, Jillian R. Gunther, John S. Comninos and John A. Katzenellenbogen*, Bioorg. Med. Chem. Lett. 2007, 17 (15), 4118-4122. (IF: 2.604)

28)Structure-Guided Optimization of Estrogen Receptor Binding Affinity and Antagonist Potency of Pyrazolopyrimidines with Basic Side Chain. Hai-Bing Zhou, Shubin Sheng, Dennis R. Compton, Younchang Kim, Andrzej Joachimiak, Sanjay Sharma, Kathryn E. Carlson, B. S. Katzenellenbogen, Kendall W. Nettles, Geoffrey L. Greene and John A. Katzenellenbogen*, J. Med. Chem. 2007, 50 (2), 399-403. (IF: 4.895)

29)Synthesis and Evaluation of Estrogen Receptor Ligands with Bridged Oxabicyclic Cores Containing a Diarylethylene Motif: Estrogen Antagonists of Unusual Structure. Hai-Bing Zhou, John S. Comninos, Fabio Stossi, Benita S. Katzenellenbogen, and John A. Katzenellenbogen*, J. Med. Chem. 2005, 48 (23), 7261-7274.